How Pa infection may affect the lungs of people with CF

Pseudomonas aeruginosa, or Pa, is one of the more common bacteria causing lung infections in people with CF.7 As Pa settles in the lungs, it can become a chronic infection that does not go away. This can worsen breathing symptoms and decrease FEV1.*8

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  • *FEV1 (Forced Expiratory Volume) measures the amount of air that can be forcefully blown out in 1 second after taking a deep breath.4

How Pa infection may affect the lungs of people with CF

How Pa infection may affect the lungs
of people with CF

As cystic fibrosis patients get older, they are more likely to have Pa infection in their lungs.7

How Pa infection may affect the lungs
of people with CF

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How Pa infection may affect the lungs
of people with CF

Patients can be infected with either the non-mucoid or mucoid strain of Pa. The mucoid strain is better able to survive within the lungs.8

While the first positive culture for many patients may be the non-mucoid strain, it could change to the mucoid strain over time.8

How Pa infection may affect the lungs
of people with CF

How Pa infection may affect the lungs
of people with CF

This mucoid Pa may form a protective layer called a biofilm. Biofilms help shield bacteria against attacks from treatments.9 They form on many surfaces, like plaque on your teeth or the slippery film on stones by a river.9

How Pa infection may affect the lungs
of people with CF

How Pa infection may affect the lungs
of people with CF

Patients with chronic Pa infections tend to have persistent symptoms, such as increased cough, wheezing, and changes in the color or amount of sputum.10,11

How Pa infection may affect the lungs
of people with CF

How Pa infection may affect the lungs
of people with CF

Once Pa settles in the lungs and becomes chronic, lung function may decline (eg, FEV1).8

How Pa infection may affect the lungs
of people with CF

What is CAYSTON?

CAYSTON is a prescription inhaled antibiotic used to improve breathing symptoms in people with cystic fibrosis (CF) who have a lung infection due to Pseudomonas aeruginosa (Pa). CAYSTON is not a treatment for infections caused by other bacteria or viruses, such as the common cold. CAYSTON is used only with the Altera® Nebulizer System. It is not known if CAYSTON is safe and effective in children under the age of 7 or in patients with FEV1 <25% or >75% predicted.