Fighting Pa infection in the lungs

Limiting your exposure to germs that cause infection and taking treatments as prescribed can help you fight the infection in your lungs.8 Your treatment plan may include a number of therapies to help improve your breathing symptoms and reduce the amount of bacteria in the airways.6

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Fighting Pa infection in the lungs

Fighting Pa infection in the lungs

Inhaled antibiotics are most often used to help fight Pa infection in the lungs.6

Fighting Pa infection in the lungs

Fighting Pa infection in the lungs

CAYSTON is a prescription inhaled antibiotic used to improve breathing symptoms in people with CF who have a chronic lung infection due to Pa.

Fighting Pa infection in the lungs

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Fighting Pa infection in the lungs

CAYSTON is delivered directly into the lungs to fight Pa at the source.

Fighting Pa infection in the lungs

Fighting Pa infection in the lungs

When CAYSTON comes into contact with the Pa in your lungs, it breaks down the bacterial cell wall and decreases the amount of bacteria by killing them.*

  • *Treatment effect seen over 28 days

Fighting Pa infection in the lungs

CAYSTON clinical trial results

CAYSTON was studied in a clinical trial of 164 CF patients, 7 years of age and older. All patients had Pa lung infection and an FEV, of 25% to 75%.12

CAYSTON clinical trial results

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CAYSTON clinical trial study design

During the study, 80 patients received CAYSTON and 84 patients received placebo (a salt solution with no medication in it) 3 times a day for 28 days by inhalation with the Altera® Nebulizer System.12

Patients used an inhaled bronchodilator (a medicine used to relax and open the airways) prior to taking CAYSTON or placebo.12

CAYSTON clinical trial study design

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What did the CAYSTON clinical trial measure?

The study looked at the effect of CAYSTON compared to placebo on:12

  • Breathing symptoms, such as coughing, wheezing, and sputum production
  • Lung function, as measured by FEV, (L)
     

What did the CAYSTON clinical trial measure?

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CAYSTON may help you breathe better

Patients treated with CAYSTON reported significant improvement in breathing symptoms like coughing, wheezing and mucus production at Day 28.

Improvements were seen in both adult and pediatric patients, but were much smaller in adult patients.

Two weeks after completion of treatment, patients treated with CAYSTON still had improved breathing symptoms compared to those who took placebo. However, the difference was smaller.12

CAYSTON may help you breathe better

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CAYSTON may help improve lung function

CAYSTON improved FEV, lung function by 10% compared to placebo.

Over the course of 28 days, patients who took CAYSTON had an average 10% increase of their starting FEV, (L) compared to patients who took placebo. Improvements in FEV1 were comparable across adult and pediatric patients on Day 28 of treatment.

This difference decreased to about 6% 2 weeks after stopping CAYSTON.12

CAYSTON may help improve lung function

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Common side effects

Common side effects of CAYSTON include:

  • Coughing
  • Nasal congestion
  • Wheezing
  • Sore throat
  • Fever (may be more common in children than in adults)
  • Chest discomfort
  • Stomach area (abdominal) pain
  • Vomiting

In a clinical trial, dysgeusia (lingering or persistent foul taste) was reported by 1 patient treated with 75mg CAYSTON and 1 placebo-treated patient.13

Common side effects

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What is CAYSTON?

CAYSTON is a prescription inhaled antibiotic used to improve breathing symptoms in people with cystic fibrosis (CF) who have a lung infection due to Pseudomonas aeruginosa (Pa). CAYSTON is not a treatment for infections caused by other bacteria or viruses, such as the common cold. CAYSTON is used only with the Altera® Nebulizer System. It is not known if CAYSTON is safe and effective in children under the age of 7 or in patients with FEV1 <25% or >75% predicted.